Figure 1.

Single intra-tumor administration of vincristine-loaded silk gel vs distributed injection, schematic and gross sections. (A) Spherical representation of tumor, r = radius, Volume = 4/3πr³. (B) Single injection into the center of tumor, r′ = radius of silk gel deposit; diffusion distance = r − r′. (C) Distributed injection into tumor at eight points using four passes with two silk gel deposits at each pass. Arrow (→): sites of gel deposit on gross specimen; astrisk (*): left kidney; dotted line: injection pass.