Figure 7.

Motor learning produces atypical structural synaptic plasticity of inputs converging on PV⁺ INs in Mecp2 KO mice. A, Representative confocal images of excitatory VGLUT1⁺ (green) and inhibitory VGAT⁺ (blue) puncta apposed to PV⁺ (red) dendrites and somata in layer II/III of M1 cortex in AC- and RR-trained WT and Mecp2 KO mice. B, C, Histograms showing quantitative analysis of VGLUT1⁺ puncta density on dendrites (B) and somata (C) of PV⁺ INs after AC and RR training. D, E, Histograms showing quantitative analysis of VGAT⁺ puncta density on dendrites (D) and somata (E) of PV⁺ INs after AC and RR training. Dendrites: n = 5 WT and 5 Mecp2 KO mice; somata: n = 6 WT and 5 Mecp2 KO mice. Two-way ANOVA and Bonferroni posthoc tests: *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar = 5 μm.