Table 2.
The mean volume diameter of vesicles in 2 formulations (F8 & F10) at different time intervals after preparation and storage at 4–8 °C and the mean of volume diameter of vesicles in 3 formulations (F3, F6, F9) at different time and temperature intervals after preparation
| Formulation code | Mean volume diameter (μm) ± SD/4–8 °C | Mean volume diameter (μm) ± SD/25 ± 2 °C-30% RH | Mean volume diameter (μm) ± SD/40 ± °C-70% RH | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 48 h | 15 days | 1 month | 3 months | 48 h | 15 days | 1 month | 3 months | 48 h | 15 days | 1 month | 3 months | |
| F3 | 8.37 ± 0.01 | 8.48 ± 0.11 | 8.41 ± 0.05 | 8.87 ± 0.49 | 8.37 ± 0.01 | 9.06 ± 0.14 | 9.81 ± 0.28 | 15.28 ± 0.60 | 8.37 ± 0.01 | 12.74 ± 0.20 | 14.09 ± 0.26 | 19.16 ± 0.14 |
| F6 | 14.25 ± 0.16 | 14.43 ± 0.47 | 15.83 ± 1.00 | 14.31 ± 0.46 | 14.25 ± 0.16 | 14.07 ± 0.36 | 12.49 ± 0.46 | 12.52 ± 0.20 | 14.25 ± 0.16 | 8.63 ± 0.21 | 8.36 ± 0.14 | 8.85 ± 0.14 |
| F8 | 8.01 ± 0.11 | 7.90 ± 0.06 | 7.88 ± 0.28 | 7.63 ± 0.06 | – | – | – | – | – | – | – | – |
| F9 | 7.52 ± 0.03 | 7.57 ± 0.15 | 7.55 ± 0.06 | 7.27 ± 0.14 | 7.52 ± 0.03 | 7.81 ± 0.08 | 7.68 ± 0.12 | 12.02 ± 0.59 | 7.52 ± 0.03 | 9.33 ± 0.32 | 10 ± 0.28 | 14.80 ± 0.83 |
| F10 | 8.31 ± 0.42 | 8.87 ± 0.0.01 | 8.76 ± 0.17 | 8.36 ± 0.27 | – | – | – | – | – | – | – | – |
| Empty niosome ST60-(S:25, T:25, Chol:50) | 8.4 ± 0.4 | 9.00 ± 0.19 | 8.88 ± 006 | 8.38 ± 0.31 | 8.4 ± 0.4 | 8.86 ± 0.23 | 9.36 ± 0.8 | 7.67 ± 0.31 | 8.4 ± 0.4 | 8.65 ± 0.07 | 8.80 ± 0.02 | 7.65 ± 0.33 |