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. 2017 Apr 16;22(4):640. doi: 10.3390/molecules22040640

Expeditious Synthesis of Dianionic-Headed 4-Sulfoalkanoic Acid Surfactants

Jianhui Jiang 1,2, Jiaxi Xu 1,*
Editor: Wim Dehaen
PMCID: PMC6154584  PMID: 28420159

Abstract

4-Sulfoalkanoic acids are a class of important dianionic-headed surfactants. Various 4-sulfoalkanoic acids with straight C8, C10, C12, C14, C16, and C18 chains were synthesized expeditiously through the radical addition of methyl 2-((ethoxycarbonothioyl)thio)acetate to linear terminal olefins and subsequent oxidation with peroxyformic acid. This is a useful and convenient strategy for the synthesis of dianionic-headed surfactants with a carboxylic acid and sulfonic acid functionalities in the head group region.

Keywords: alkanoic acid, double head, oxidation, radical reaction, surfactant, xanthate

1. Introduction

Surfactants have been widely applied in almost every fields, including personal care and industry [1]. Numerous gemini surfactants have been prepared and investigated during the last several decades [2,3]. Recently, much attention has been paid to the preparation and properties of double-headed and double-tailed surfactants [4,5,6,7]. Only a few double-tailed surfactants have been prepared, and their surfactant activity has not been evaluated until now [4,5]. Double-headed surfactants have been utilized in the industry as wetting agents and dispersants (Figure 1) [6,7]. They have been generally prepared from maleic anhydride and maleate-monoester/diesters [8,9]. There is considerable and still increasing interest in the synthesis of new double-headed surfactants with two different dianionic heads, because dianionic-headed surfactants with two hydrophilic head groups and one hydrophobic tail with a head to tail ratio of 2:1 generally show good wetting and low foam properties alongside mild surface activity. They may find applications in the textile industry [7] and colloidal drug delivery system [10]. Zard’s xanthate radical addition chemistry promotes us to develop a new strategy to synthesize a series of novel dianionic-headed surfactants with a carboxylic acid and sulfonic acid functionalities in the head group region [11,12,13,14,15]. Herein, we present an expeditious synthesis of dianionic-headed surfactant 4-sulfoalkanoic acids through the radical addition of methyl 2-((ethoxycarbonothioyl)thio)acetate to linear terminal olefins and subsequent oxidation with peroxyformic acid (Scheme 1).

Figure 1.

Figure 1

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Some reported dianionic-headed surfactants.

Scheme 1.

Scheme 1

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Synthesis of dianionic-headed 4-sulfoalkanoic acid surfactants.

2. Results and Discussion

Methyl 2-((ethoxycarbonothioyl)thio)acetate 1 was prepared from potassium O-ethylxanthate and methyl chloroacetate [16]. Reactions of methyl 2-((ethoxycarbonothioyl)thio)acetate 1 and linear terminal olefins 2, including 1-hexene, 1-octene, 1-decene, 1-dodecene, 1-tetradecene, and 1-hexadecene, under radical initiator dilauroyl peroxide (DLP) in 1,2-dichloroethane (DCE) as a solvent gave rise to a series of xanthates, methyl 2-((ethoxycarbonothioyl)thio)alkanoates 3 in good to excellent yields (Scheme 2 and Table 1) (Supplementary materials) [17].

Scheme 2.

Scheme 2

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Synthesis of xanthates 3.

Table 1.

Radical addition of methyl 2-((ethoxycarbonothioyl)thio)acetate 1 with olefins 2.

Entry Olefin 2/R Xanthate 3 Yield (%)
1 nBu 3a 79
2 nHex 3b 86
3 nOct 3c 88
4 nDecyl 3d 86
5 nDodecyl 3e 80
6 nTetradecyl 3f 87
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Through the previously mentioned oxidation procedure with peroxyformic acid [18,19,20], all xanthates 3 were converted into the corresponding 4-sulfoalkanoic acids 4 in almost quantitative yields. Under the current acidic oxidation conditions, the xanthate group was oxidized into sulfonic acid and the methyl-carboxylate group in xanthates 3 was hydrolyzed into the carboxylic acid group (Supplementary materials) (Table 2 and Scheme 3).

Table 2.

Synthesis of 4-Sulfoalkanoic acids 4.

Entry Xanthate 3 R Acid 4 Yield (%)
1 3a nBu 4a 99
2 3b nHex 4b 98
3 3c nOct 4c 99
4 3d nDecyl 4d 99
5 3e nDodecy 4e 98
6 3f nTetradecyl 4f 99
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Scheme 3.

Scheme 3

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Synthesis of 4-Sulfoalkanoic acids 4.

The designed synthetic strategy shows excellent efficiency with the following advantages; simple and inexpensive starting materials, a two-step synthetic route, good to excellent yields, and easy purification in the last step.

We previously prepared taurine and homotaurine derivatives by oxidation of thioacetates [21,22,23,24,25] and xanthates [18,19,20]. Douglass and his coworkers reported that xanthates (ROCS2R’) were chlorinated into alkoxydichloromethanesulfenyl chlorides (ROCCl2SCl) and alkylsulfur trichlorides (R’SCl3) with chlorine under anhydrous conditions [26,27]. On the basis of above results and our recent results of the oxidative chlorination [28], the mechanism of the oxidation of xanthates 3 into 4-sulfoalkanoic acids 4 with peroxyformic acid was proposed, as shown in Scheme 4. Initially, the sulfur atom in the thioxo group of xanthates 3 is oxidized with peroxyformic acid, generating intermediates A. Intermediates A are attacked by water in the reaction system to generate intermediates B, of which the sulfur atom in their thioether part is further oxidized by another molecule of peroxyformic acid to produce intermediates C. Unstable intermediates C decompose into ethoxycarbonylsulfenic acid (5) and 1-(3-methoxy-3-oxopropyl)alkanesulfenic acids 6 under acidic conditions.

Scheme 4.

Scheme 4

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Plausible mechanism for the oxidation of methyl 2-((ethoxycarbonothioyl)thio)alkanoates 3 to 4-sulfoalkanoic acids 4.

Both ethoxycarbonylsulfenic acid 5 and 1-(3-methoxy-3-oxopropyl)alkanesulfenic acids 6 are further oxidized into the corresponding sulfonic acids 9 and 10, respectively, with peroxyformic acid following the same mechanism.

Unstable ethoxycarbonylsulfonic acid 9 tautomerizes into intermediate D, in which its carbonyl group is protonated by dissociated sulfonic acid. Intermediate D is attacked by water, giving rise to intermediate E, which is more unstable and finally decomposes into ethanol, CO2, SO3, and proton. 1-(3-Methoxy-3-oxopropyl)alkanesulfonic acids 9 are further hydrolyzed into 4-sulfoalkanoic acids 4 under acidic conditions (Scheme 4).

3. Materials and Methods

3.1. Materials and Instruments

Melting points were measured on a Yanaco MP-500 melting point apparatus (Yanaco Ltd., Osaka, Japan) and are uncorrected. 1H-NMR and 13C-NMR spectra were recorded with a Bruker 400 spectrometer (Bruker Company, Billerica, MA, USA) in CDCl3 with tetramethylsilane (TMS) as an internal standard, or in D2O with DOH as an internal standard in 1H-NMR, or with HCO2H (166.3 ppm) as an internal standard in 13C-NMR. IR spectra were obtained on a Nicolet AVATAR 330 FTIR spectrometer (Thermo Nicolet Corporation, Madison, WI, USA). HRMS spectra were recorded with a Liquid Chromatography/Mass Spectrometry/Data and Time-of-Flight (LC/MSD TOF) mass spectrometer (Agilent, Santa Clara, CA, USA). TLC analysis was performed on glass pre-coated silica gel YT257‒85 (10‒40 µm) plate (Qingdao Ocean Chemical Industry, Qingdao, China). Spots were visualized with UV light or iodine. Column chromatography was performed on silica gel zcx II (200‒300 mesh) (Qingdao Ocean Chemical Industry, Qingdao, China) with petroleum-ether (PE) and ethyl-acetate (EA) (Beijing Chemical Reagent Company, Beijing, China) as the eluent.

3.2. Synthesis of Methyl 2-((Ethoxycarbonothioyl)thio)acetate (1) [16,17]

To a solution of methyl-chloroacetate (4.175 g, 25 mmol) in acetone (40 mL) precooled at 0 °C, potassium-O-ethyl-dithiocarbonate (4.232 g, 27 mmol) was added portionwise while stirring at 0 °C. After the addition, the mixture was allowed to warm to room temperature under continuous stirring. After the removal of acetone, the residue was dissolved in water (50 mL) and the mixture was extracted with CH2Cl2 (3×50 mL). The combined organic phase was dried over MgSO4. After the removal of solvents, the residue was purified on a silica gel column with petroleum ether and ethyl acetate (15:1, v/v) as the eluent to afford the desired xanthate 1, 4.032 g (83% yield). Its analytic data are identical to the reported ones.

3.3 General Procedure for the Synthesis of Methyl-2-((ethoxycarbonothioyl)thio)alkanoates 3

A stirred solution of olefin 2 (8 mmol) and methyl 2-((ethoxycarbonothioyl)thio)acetate (1) (1.554 g, 8 mmol) in 1,2-dichloroethane (12 mL) was heated at reflux for 15 min. dilauroyl peroxide (DLP) (168 mg, 5 mol %) was added and additional DLP (168 mg, 5 mol %) was added each hour until the methyl 2-((ethoxycarbonothioyl)thio)acetate (1) was consumed completely (generally 3 h). The mixture was allowed to cool to room temperature. After the solvent was evaporated under reduced pressure, the residue was purified by flash chromatography on silica gel with a mixture of petroleum-ether and ethyl-acetate (40:1, v/v) as the eluent to afford the desired product 3.

3.3.1. Methyl 2-((ethoxycarbonothioyl)thio)octanoate (3a)

Yellow oil; yield: 1.756 g (79%). 1H-NMR (400 MHz, CDCl3): δ = 0.90 (t, J = 7.2 Hz, 3H, CH3), 1.25−1.40 (m, 4H, 2CH2), 1.42 (t, J = 7.1 Hz, 3H, CH3), 1.66 (q, J = 7.3 Hz, 2H, CH2), 1.86−1.96 (m, 1H in CH2), 2.06−2.15 (m, 1H in CH2), 2.47 (dt, J = 1.4, 7.4 Hz, 2H, CH2), 3.68 (s, 3H, CH3), 3.76 (quint, J = 6.8 Hz, 1H, CH), 4.64 (q, J = 7.2 Hz, 2H, CH2). 13C-NMRNMR (101 MHz, CDCl3): δ = 13.8, 13.9, 22.5, 28.9, 29.5, 31.4, 34.0, 50.7, 51.7, 69.8, 173.5, 214.4. IR (KBr): 2955.3, 2929.3, 2857.9, 1739.9, 1436.8, 1212.5, 1111.4, 1050.1. cm-1 HRMS (ESI): m/z calcd for C12H23O3S2+: 279.1083 [M + H]+; found: 279.1080.

3.3.2. Methyl-2-((ethoxycarbonothioyl)thio)decanoate (3b)

Yellow oil; yield: 2.105 g (86%). 1H-NMR (400 MHz, CDCl3): δ = 0.88 (t, J = 7.0 Hz, 3H, CH3), 1.25−1.35 (m, 7H, 3CH2 & 1H in CH2), 1.42 (t, J = 7.1 Hz, 3H, CH3), 1.36−1.48 (m, 1H in CH2), 1.66 (q, J = 7.1 Hz, 2H, CH2), 1.86−1.96 (m, 1H in CH2), 2.05−2.15 (m, 1H in CH2), 2.48 (dt, J = 1.4, 7.0 Hz, 2H, CH2), 3.68 (s, 3H, CH3), 3.76 (quint, J = 6.8, 1H, CH), 4.64 (q, J = 7.2 Hz, 2H, CH2). 13C-NMRNMR (101 MHz, CDCl3): δ = 13.8, 14.0, 22.6, 26.7, 29.1, 29.5, 31.4, 31.6, 34.3, 50.8, 51.7, 69.8, 173.5, 214.4. IR (KBr): 2953.6, 2927.2, 2855.8, 1740.2, 1436.5, 1365.8, 1212.8, 1111.3, 1050.6 cm−1. HRMS (ESI): m/z calcd for C14H27O3S2+: 307.1396 [M + H]+; found: 307.1391.

3.3.3. Methyl-2-((ethoxycarbonothioyl)thio)dodecanoate (3c)

Yellow oil; yield: 2.348 g (88%). 1H-NMR (400 MHz, CDCl3): δ = 0.88 (t, J = 7.0 Hz, 3H, CH3), 1.23−1.30 (m, 11H, 5CH2 & 1H in CH2), 1.42 (t, J = 7.1 Hz, 3H, CH3), 1.35−1.45(m, 1H in CH2), 1.67 (q, J = 7.1 Hz, 2H, CH2), 1.86−1.96 (m, 1H in CH2), 2.06−2.14 (m, 1H in CH2), 2.40−2.53 (m, 2H, CH2), 3.67 (s, 3H, CH3), 3.75 (quint, J = 6.8 Hz, 1H, CH), 4.64 (q, J = 7.1 Hz, 2H, CH2). 13C-NMRNMR (101 MHz, CDCl3): δ = 13.8, 14.1, 22.6, 26.8, 29.2, 29.4(2C), 29.5, 31.3, 31.8, 34.3, 50.8, 51.6, 69.8, 173.5, 214.4. IR (KBr): 2951.9, 2925.6, 2854.4, 1740.6, 1436.5, 1365.6, 1212.6, 1111.4, 1051.3 cm−1. HRMS (ESI): m/z calcd for C16H31O3S2+: 335.1709 [M + H]+; found: 335.1702.

3.3.4. Methyl-2-((ethoxycarbonothioyl)thio)tetradecanoate (3d)

Yellow oil; yield: 2.491 g (86%). 1H-NMR (400 MHz, CDCl3): δ = 0.88 (t, J = 7.0 Hz, 3H, CH3), 1.23−1.28 (m, 15H, 7CH2& 1H in CH2), 1.42 (t, J = 7.1 Hz, 3H, CH3), 1.39−1.44 (m, 1H in CH2), 1.65 (q, J = 7.0 Hz, 2H, CH2), 1.86−1.96 (m, 1H in CH2), 2.06−2.14 (m, 1H in CH2), 2.40−2.53 (m, 2H, CH2), 3.67 (s, 3H, CH3), 3.72−3.79 (m, 1H, CH), 4.64 (q, J = 7.1 Hz, 2H, CH2). 13C-NMR (101 MHz, CDCl3): δ = 13.7, 14.1, 22.6, 26.8, 29.27, 29.37, 29.41, 29.45, 29.52, 29.54, 31.3, 31.9, 34.2, 50.8, 51.6, 69.8, 173.5, 214.4. IR (KBr): 2924.2, 2853.9, 1740.5, 1436.7, 1365.5, 1212.5, 1111.4, 1051.6 cm−1. HRMS (ESI): m/z calcd for C18H35O3S2+: 363.2022 [M + H]+; found: 363.2016.

3.3.5. Methyl-2-((ethoxycarbonothioyl)thio)hexadecanoate (3e)

Yellow oil; yield: 2.498 g (80%). 1H-NMR (400 MHz, CDCl3): δ = 0.88 (t, J = 7.0 Hz, 3H, CH3), 1.23−1.28 (m, 19H, 9CH2 & 1H in CH2), 1.42 (t, J = 7.1 Hz, 3H, CH3), 1.39−1.44 (m, 1H in CH2), 1.65 (q, J = 6.9 Hz, 2H, CH2), 1.86−1.96 (m, 1H in CH2), 2.06−2.14 (m, 1H in CH2), 2.40−2.53 (m, 2H, CH2), 3.67 (s, 3H, CH3), 3.72−3.79 (m, 1H, CH), 4.64 (q, J = 7.1 Hz, 2H, CH2). 13C-NMRNMR (101 MHz, CDCl3): δ = 13.8, 14.1, 22.7, 26.8, 29.32, 29.38, 29.42, 29.45, 29.53, 29.59, 29.60, 29.62, 31.3, 31.9, 34.3, 50.8, 51.6, 69.8, 173.4, 214.4. IR (KBr): 2923.5, 2852.9, 1739.9, 1436.1, 1365.9, 1211.9, 1111.3, 1050.3 cm−1. HRMS (ESI): m/z calcd for C20H39O3S2+: 391.2335 [M + H]+; found: 391.2330.

3.3.6. Methyl-2-((ethoxycarbonothioyl)thio)octadecanoate (3f)

Yellow oil; yield: 2.917 g (87%). 1H-NMR (400 MHz, CDCl3): δ = 0.89 (t, J = 6.9 Hz, 3H, CH3), 1.24−1.35 (m, 23H, 11CH2 & 1H in CH2), 1.43 (t, J = 7.0 Hz, 3H, CH3), 1.41−1.47(m, 1H in CH2), 1.67 (q, J = 7.3 Hz, 2H, CH2), 1.88−1.97 (m, 1H in CH2), 2.07−2.16 (m, 1H in CH2), 2.42−2.54 (m, 2H, CH2), 3.69 (s, 3H, CH3), 3.77 (quint, J = 6.7, 1H, CH), 4.64 (q, J = 7.0 Hz, 2H, CH2). 13C-NMRNMR (101 MHz, CDCl3): δ = 13.8, 14.1, 22.7, 26.8, 29.36, 29.42, 29.45, 29.46, 29.49, 29.57, 29.63, 29.66, 29.68, 29.69, 31.4, 31.9, 34.3, 50.8, 51.6, 69.8, 173.4, 214.4. IR (KBr): 2924.0, 2853.1, 1741.1, 1436.5, 1366.0, 1211.8, 1111.4, 1051.4 cm−1. HRMS (ESI): m/z calcd for C22H43O3S2+: 419.2648 [M + H]+; found: 419.2641.

3.4. General procedure for the synthesis of 4-sulfonylalkanoic acids 4

To a stirred and mixed solution of 98% formic acid (15 mL) and 30% H2O2 (10 mL), xanthate 3 (3 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 2 h and then at 65 °C overnight. The removal of solvents in a vacuum afforded 4-sulfoalkanoic acid 4.

3.4.1. 4-Sulfooctanoic acid (4a)

Yellow oil; yield: 666 mg (99%). 1H-NMR (400 MHz, D2O): δ = 0.53 (t, J = 7.2 Hz, 3H, CH3), 0.91−1.03 (m, 2H, CH2), 1.03−1.13 (m, 2H, CH2), 1.13−1.25 (m, 1H in CH2), 1.41−1.56 (m, 1H in CH2), 1.56−1.70 (m, 1H in CH2), 1.70−1.75 (m, 1H in CH2), 2.21−2.30 (m, 2H, CH2), 2.45−2.50 (m, 1H, CH). 13C-NMR (101 MHz, D2O): δ = 13.8, 21.6, 25.2, 29.0, 29.5, 31.9, 59.7, 178.5. IR (KBr): 2925.9, 2855.2, 1738.9, 1228.2, 1168.4, 1077.7, 1053.6 cm−1. HRMS (ESI): m/z calcd for C8H15O5S−: 223.0646 [M − H]−; found: 223.0643.

3.4.2. 4-Sulfodecanoic acid (4b)

Colorless oil; yield: 742 mg (98%). 1H-NMR (400 MHz, D2O): δ = 0.45 (t, J = 6.4 Hz, 3H, CH3), 0.80−0.95 (m, 6H, 3CH2), 0.96−1.07 (m, 2H, CH2), 1.08−1.22 (m, 1H in CH2), 1.41−1.50 (m, 1H in CH2), 1.51−1.60 (m, 1H in CH2), 1.60−1.70 (m, 1H in CH2), 2.13−2.23 (m, 2H, CH2), 2.34−2.45 (m, 1H, CH). 13C-NMR (101 MHz, D2O): δ = 14.3, 22.8, 25.2, 27.1, 29.3, 29.9, 31.8, 31.9, 59.7, 178.2. IR (KBr): 2927.5, 2856.9, 1712.2, 1230.1, 1169.1, 1078.4, 1054.2 cm−1. HRMS (ESI): m/z calcd for C10H19O5S−: 251.0959 [M − H]−; found: 251.0954.

3.4.3. 4-Sulfododecanoic acid (4c)

Colorless oil; yield: 832 mg (99%). 1H-NMR (400 MHz, D2O): δ = 0.40 (t, J = 6.4 Hz, 3H, CH3), 0.75−0.98 (m, 12H, 6CH2), 1.00−1.11 (m, 1H in CH2), 1.35−1.51 (m, 2H, CH2), 1.51−1.60 (m, 1H in CH2), 2.04−2.20 (m, 2H, CH2), 2.25−2.37 (m, 1H, CH). 13C-NMR (101 MHz, D2O): δ = 14.5, 23.2, 25.2, 27.6, 29.9, 30.0, 30.1. 30.3, 31.0, 32.5, 59.8, 177.8. IR (KBr): 2926.0, 2855.8, 1709.8, 1230.5, 1169.4, 1053.9 cm−1. HRMS (ESI): m/z calcd for C12H23O5S−: 279.1272 [M − H]−; found: 279.1270.

3.4.4. 4-Sulfotetradecanoic acid (4d)

Colorless oil; yield: 916 mg (99%). 1H-NMR (400 MHz, D2O): δ = 0.44 (t, J = 6.5 Hz, 3H, CH3), 0.83−1.05 (m, 16H, 8CH2), 1.14−1.20 (m, 1H in CH2), 1.39−1.55 (m, 2H, CH2), 1.55−1.65 (m, 1H in CH2), 2.10−2.21 (m, 2H, CH2), 2.33−2.44 (m, 1H, CH). 13C-NMR (101 MHz, D2O): δ = 14.5, 23.3, 25.2, 27.7, 30.16, 30.19, 30.4. 30.5, 30.66, 30.70, 31.0, 31.8, 59.8, 177.7. IR (KBr): 2924.5, 2854.1, 1710.9, 1231.5, 1170.0, 1077.8, 1054.2 cm−1. HRMS (ESI): m/z calcd for C14H27O5S−: 307.1585 [M − H]−; found: 307.1581.

3.4.5. 4-Sulfohexadecanoic acid (4e)

Colorless oil; yield: 989 mg (98%). 1H-NMR (400 MHz, D2O): δ = 0.58 (t, J = 6.4 Hz, 3H, CH3), 0.90−1.07 (m, 20H, 10CH2), 1.16−1.28 (m, 1H in CH2), 1.50−1.71 (m, 2H, CH2), 1.71−1.76 (m, 1H in CH2), 2.20−2.35 (m, 2H, CH2), 2.43−2.53 (m, 1H, CH). 13C-NMR (101 MHz, D2O): δ = 14.5, 23.3, 25.2, 27.8, 29.4, 29.6, 29.7, 29.8. 29.9, 30.2, 30.4, 30.5, 30.6, 30.7, 31.1, 31.9, 59.8, 177.7. IR (KBr): 2924.6, 2853.9, 1710.5, 1288.0, 1069.2, 1011.8 cm−1. HRMS (ESI): m/z calcd for C16H31O5S−: 335.1898 [M − H]−; found: 335.1892.

3.4.6. 4-Sulfooctadecanoic acid (4f)

Colorless oil; yield: 1.083 g (99%). 1H-NMR (400 MHz, D2O): δ = 0.75 (t, J = 7.2 Hz, 3H, CH3), 1.07−1.27 (m, 24H, 12CH2), 1.43−1.49 (m, 1H in CH2), 1.66−1.81 (m, 2H, CH2), 1.81−1.96 (m, 1H in CH2), 2.40−2.50 (m, 2H, CH2), 2.53−2.67 (m, 1H, CH). 13C-NMR (101 MHz, D2O): δ = 14.6, 23.4, 24.5, 27.0, 29.4, 29.6, 29.74, 29.76. 29.79, 30.4, 30.5, 30.6, 30.7, 30.8, 31.1, 31.9, 59.8, 177.7. IR (KBr): 2924.3, 2854.2, 1710.2, 1288.3, 1069.0, 1011.6 cm−1. HRMS (ESI): m/z calcd for C18H35O5S−: 363.2211 [M − H]−; found: 363.2205.

4. Conclusions

A series of 4-sulfoalkanoic acids with straight C8, C10, C12, C14, C16, and C18 chains was prepared effectively from simple and inexpensive starting materials through the radical addition of methyl 2-((ethoxycarbonothioyl)thio)acetate to linear terminal olefins and subsequent oxidation with peroxyformic acid. The current strategy is a useful and convenient route for the synthesis of dianionic-headed surfactants with a carboxylic acid and sulfonic acid functionalities in the head group region.

Acknowledgments

This work was supported in part by the National Basic Research Program of China (No. 2013CB328905), and the National Natural Science Foundation of China (Nos. 21372025 and 21172017).

Supplementary Material

Supplmentary materials are available online. Copies of 1H-NMR and 13C-NMR spectra of unknown compounds 3 and 4 are included in the Supporting Information.

Click here for additional data file. (1.4MB, pdf)

Author Contributions

Jiaxi Xu conceived and designed the experiments; Jianhui Jiang performed the experiments; Jiaxi Xu and Jianhui Jiang analyzed the data; Jiaxi Xu wrote the paper.

Conflicts of Interest

The authors declare no conflict of interest.

Footnotes

Sample Availability: Samples of the compounds 3 and 4 are not available from the authors.

References

  • 1.Rosen M.J. Surfactants and Interfacial Phenomenon: Characteristic feature of surfactant. 3rd ed. Wiley; Hoboken, NJ, USA: 2004. pp. 1–32. [Google Scholar]
  • 2.Yoshimura T., Bong M., Matsuoka K., Honda C., Endo K. Surface properties and aggregate morphology of partially fluorinated carboxylate-type anionic gemini surfactants. J. Colloid Interf. Sci. 2009;339:230–235. doi: 10.1016/j.jcis.2009.07.054. [DOI] [PubMed] [Google Scholar]
  • 3.Karpichev Y., Jahan N., Paul N., Petropolis C.P., Mercer T., Grindley T.B., Marangoni D.G. The micellar and surface properties of a unique type of two-headed surfactant–pentaerythritol based dicationic surfactants. J. Colloid Interf. Sci. 2014;423:94–100. doi: 10.1016/j.jcis.2014.02.017. [DOI] [PubMed] [Google Scholar]
  • 4.Gong Q.T., Wang L., Wang D.X. Synthesis of sodium di-n-alkylbenzenesulfonates and study of their interfacial activities. Fine Chem. 2005;22:189–191. [Google Scholar]
  • 5.Hou S.L., Xu J.X. Synthesis and properties of double-tail surfactants sodium di-n-alkylphenyl unsaturated carboxylates. Chem. Reagents. 2013;35:345–348. [Google Scholar]
  • 6.Zhu Y.P., Masuyama A., Kobata Y., Nakatsuji Y., Okahara M., Rosen M.J. Double-chain surfactants with two carboxylate groups and their relation to similar double-chain compounds. J. Colloid Interf. Sci. 1993;158:40–46. doi: 10.1006/jcis.1993.1226. [DOI] [Google Scholar]
  • 7.Kumar P.P., Ramesh P., Kanjilal S. Sulfosuccination of methyl ricinoleate and methyl 12-hydroxy stearate derived from renewable castor oil and evaluation of their surface properties. J. Surfact. Deterg. 2016;19:447–454. doi: 10.1007/s11743-016-1804-0. [DOI] [Google Scholar]
  • 8.Vibhute B.P., Khotpal R.R., Karadbhajane V.Y., Kulkami A.S. Preparation of maleinized castor oil (MCO) by conventional method and its application in the formulation of liquid detergent. Int. J. Chem. Tech. Res. 2013;5:1886–1896. [Google Scholar]
  • 9.Li X., Hu Z., Zhu H., Zhjao S., Cao D. Synthesis and properties of novel alkyl sulfonate gemini surfactants. J. Surfact. Deterg. 2010;13:353–359. doi: 10.1007/s11743-010-1188-5. [DOI] [Google Scholar]
  • 10.Kalhapure R.S., Akamanchi K.G. A novel biocompatible bicephalous dianionic surfactant from oleic acid for solid lipid nanoparticles. Colloid Surface B. 2013;105:215–222. doi: 10.1016/j.colsurfb.2013.01.011. [DOI] [PubMed] [Google Scholar]
  • 11.Debien L., Quiclet-Sire B., Zard S.Z. Allylic alcohols: Ideal radical allylating agents? Acc. Chem. Res. 2015;48:1237–1253. doi: 10.1021/acs.accounts.5b00019. [DOI] [PubMed] [Google Scholar]
  • 12.Quiclet-Sire B., Zard S.Z. Powerful carbon-carbon bond forming reactions based on a novel radical exchange process. Chemistry. 2006;12:6002–6016. doi: 10.1002/chem.200600510. [DOI] [PubMed] [Google Scholar]
  • 13.Quiclet-Sire B., Zard S.Z. The xanthate route to amines, anilines, and other nitrogen compounds. A brief account. Synlett. 2016;27:680–701. [Google Scholar]
  • 14.Huang Z.Y., Xu J.X. One-pot synthesis of symmetric 1,7-dicarbonyl compounds via a tandem radical addition-elimination-addition reaction. RSC Adv. 2013;3:15114–15120. doi: 10.1039/c3ra42932f. [DOI] [Google Scholar]
  • 15.Kakaei S., Xu J.X. Synthesis of (2-alkylthiothiazolin-5-yl)methyl dodecanoates via tandem radical reaction. Org. Biomol. Chem. 2013;11:5481–5490. doi: 10.1039/c3ob41229f. [DOI] [PubMed] [Google Scholar]
  • 16.Kakaei S., Chen N., Xu J.X. Efficient synthesis of protected sulfonopeptides from N-protected 2-aminoalkyl xanthates and thioacetates. Tetrahedron. 2013;69:9068–9075. doi: 10.1016/j.tet.2013.08.028. [DOI] [Google Scholar]
  • 17.Kakaei S., Xu J.X. An expeditious synthesis of 1-substituted and cyclic taurines. Tetrahedron. 2013;69:302–309. doi: 10.1016/j.tet.2012.10.029. [DOI] [Google Scholar]
  • 18.Xu C.X., Xu J.X. Versatile synthesis of α-substituted taurines from nitroolefins. Amino Acids. 2011;41:195–203. doi: 10.1007/s00726-010-0655-7. [DOI] [PubMed] [Google Scholar]
  • 19.Chen N., Jia W.Y., Xu J.X. A versatile synthesis of various substituted taurines from vicinal amino alcohols and aziridines. Eur. J. Org. Chem. 2009;33:5841–5846. doi: 10.1002/ejoc.200900759. [DOI] [Google Scholar]
  • 20.Huang Z.Y., Xu J.X. Efficient synthesis of N-protected 1-substituted homotaurines from a xanthate and olefins. Tetrahedron. 2013;69:1050–1056. doi: 10.1016/j.tet.2012.11.074. [DOI] [Google Scholar]
  • 21.Chen N., Xu J.X. Facile synthesis of various substituted taurines, especially syn- and anti-1,2-disubstituted taurines, from nitroolefins. Tetrahedron. 2012;68:2513–2522. doi: 10.1016/j.tet.2012.01.031. [DOI] [Google Scholar]
  • 22.Ma Y.H., Xu J.X. Synthesis of homotaurine and 1-substituted homotaurines from α,β-unsaturated nitriles. Synthesis. 2012;44:2225–2230. [Google Scholar]
  • 23.Nai Y.F., Xu J.X. Synthesis of substituted homotaurines from 2-alkenamides. Helv. Chim. Acta. 2013;96:1355–1365. doi: 10.1002/hlca.201200547. [DOI] [Google Scholar]
  • 24.Xu J.X., Xu S. A general route to synthesis of N-protected 1-substituted and 1,2-disubstituted taurines. Synthesis. 2004:276–282. doi: 10.1055/s-2003-44382. [DOI] [Google Scholar]
  • 25.Zheng Y.P., Xu J.X. Synthesis of enantiopure free and N-benzyloxycarbonyl-protected 3-substituted homotaurines from naturally occurring amino acids. Tetrahedron. 2014;70:5197–5206. doi: 10.1016/j.tet.2014.05.098. [DOI] [Google Scholar]
  • 26.Douglass I.B., Johnson T.B. The interaction of chlorine with different types of organic sulfur compounds. J. Am. Chem. Soc. 1938;60:1486–1489. doi: 10.1021/ja01273a062. [DOI] [Google Scholar]
  • 27.Douglass I.B., Osborne C.E. The anhydrous chlorination of thioesters and related compounds. J. Am. Chem. Soc. 1953;75:4582–4583. doi: 10.1021/ja01114a506. [DOI] [Google Scholar]
  • 28.Abdellaoui H., Chen X.P., Xu J.X. Efficient synthesis of N-benzyloxycarbonyl-2-aminoalkanesulfonyl chlorides with functionalized side-chains. Synthesis. 2017;49:1632–1640. [Google Scholar]

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