Table 1.

Calculated activity and toxicity in silico profiles for compounds 1–8 and antiprotozoal choice drugs.

Compound	Antiparasitic Effect (Trichomonas vaginalis)		LD50 (mg/Kg)
			Mouse		Rat
	Pa	Pi	ip	p.o.	ip	po
1	0.313	0.023	300	1300	430	1200
2	0.319	0.020	460	1600	330	830
3	0.250	0.065	490	830	530	670
4	0.304	0.027	490	840	460	970
5	0.201	0.122	380	960	800	320
6	0.324	0.018	430	1200	1200	670
7	0.292	0.033	290	920	280	900
8	0.201	0.122	280	1100	440	750
10	0.333	0.015	150	1200	480	620
Bnz	0.705	0.002	1100	280	1300	1100

Pa = Probability of activity Pi = Probability of inactivity ip = Intraperitoneal po = Oral.