Table 1.
IC50 values of melatonin and 2-hydroxymelatonin.
| Viability (%) | Caco2 | HCT116 | DLD1 | CT26 | ||||
|---|---|---|---|---|---|---|---|---|
| M | 2-OH-M | M | 2-OH-M | M | 2-OH-M | M | 2-OH-M | |
| 2000 μM | 31.7 | 24.1 | 58.0 | 32.2 | 66.5 | 42.2 | 53.7 | 7.6 |
| 1000 μM | 65.1 | 60.9 | 73.8 | 74.3 | 86.1 | 93.0 | 67.8 | 58.6 |
| 500 μM | 83.3 | 71.2 | 85.4 | 91.5 | 98.0 | 93.6 | 89.1 | 91.3 |
| 250 μM | 95.3 | 78.3 | 97.4 | 104.6 | 98.1 | 96.0 | 99.1 | 104.8 |
| IC50 (μM) | 1324.6 ± 69.18 | 1010.3 ± 28.0 | 2537.4 ± 311.4 | 1482.3 ± 67.4 | 3617.1 ± 594.3 | 2136.5 ± 84.8 | 1980.9 ± 14.8 | 1036.1 ± 25.7 |
| p-value | 0.014 | 0.029 | 0.043 | <0.001 | ||||
Data represent the mean value from three independent experiments. p-value was obtained between the M and 2-OH-M treated group of each cell. M: melatonin; 2-OH-M: 2-hydroxymelatonin.