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Both of these cyclodextrin-based probes respond selective to Zn2+. With 26, Zn2+ is thought to coordinate to the amines and hydroxyl group, triggering fluorescence enhancement and blue shift from 460 nm to 410 nm in water [101]. The bis-CD probe 27 responds to Zn2+ with fluorescence enhancement and a red-shift in the emission wavelength from 368 to 377 nm [102].
