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Schematic representation of the main diabetes-related targets of phlorotannins (AGEs: advanced glycation end-products; Akt: protein kinase B; AMPK: AMP-activated protein kinase; DDBT: 2-(4-(3,5-dihydroxyphenoxy)-3,5-dihydroxyphenoxy) benzene-1,3,5-triol; G6P: glucose-6-phosphatase; GLUT4: glucose transporter 4; PEPCK: phosphoenolpyruvatecarboxykinase; PTP1B: protein tyrosine phosphatase 1B; ROS: reactive oxygen species).
