Table 9.
Comparison of the Pharmacokinetic Profile of the GC and HYD-HZ Groups.
| Compound No. | Group | Cmax/ng·mL−1 | Tmax/h | T1/2/h | AUC0~t/ng·h·mL−1 |
|---|---|---|---|---|---|
| 2 | HYD | 612.10 ± 200.05 | 0.17 ± 0.09 | 11.33 ± 4.86 | 911.65 ± 197.89 |
| HYD-GH | 423.79 ± 188.45 | 0.15 ± 0.10 | 1.23 ± 0.15 ## | 565.30 ± 351.95 | |
| 3 | HYD | 302.93 ± 95.12 | 0.24 ± 0.21 | 1.15 ± 0.34 | 359.29 ± 120.84 |
| HYD-GH | 119.82 ± 21.24 ## | 0.17 ± 0 | 0.52 ± 0.50 # | 100.09 ± 44.85 ## | |
| 4 | HYD | 119.89 ± 68.18 | 4.38 ± 4.76 | 30.56 ± 13.26 | 3795.89 ± 2093.85 |
| HYD-GH | 122.63 ± 0.15 | 0.17 ± 0.15 | 4.52 ± 0.56 ## | 501.22 ± 414.00 # | |
| 5 | HYD | 197.09 ± 115.14 | 3.17 ± 2.56 | 3.44 ± 2.84 | 1170.96 ± 569.74 |
| HYD-GH | 302.24 ± 62.36 | 3.11 ± 1.44 | 4.70 ± 1.96 | 1043.15 ± 549.78 | |
| 8 | HYD | 226.76 ± 57.80 | 0.33 ± 0.21 | 1.56 ± 1.02 | 819.43 ± 25.72 |
| HYD-GC-HZ | 125.28 ± 35.61 | 0.11 ± 0.04 ## | 9.60 ± 10.61 | 785.69 ± 369.20 ## | |
| 9 | HYD | 1000.95 ± 178.16 | 0.67 ± 0 | 6.03 ± 1.95 | 2865.70 ± 285.38 |
| HYD-GH | 311.16 ± 126.03 ## | 0.46 ± 0.37 | 3.26 ± 3.53 | 1182.52 ± 539.49 ## | |
| 10 | HYD | 457.96 ± 184.11 | 0.61 ± 0.14 | 1.25 ± 0.03 | 748.45 ± 224.96 |
| HYD-GH | 69.22 ± 25.57 ## | 0.53 ± 0.31 | 0.68 ± 0.49 # | 98.46 ± 40.96 ## |
# Difference compared with the corresponding HYD group, p < 0.05; ## Difference compared with the corresponding HYD group, p < 0.01.