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. 2018 Sep 12;141(10):2848–2854. doi: 10.1093/brain/awy240

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© The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Association between apathy severity and ¹²³I-ioflupane SPECT/CT signal in the DRN. (A) Standard space T₁-weighted MRI template with regions of interest for the dorsal (red) and median (blue) raphe nuclei from the Harvard Ascending Arousal Network Atlas overlaid. (B–C) Illustrative example images from two patients with RBD, with SPECT/CT images registered to standard space and overlaid on the standard MRI template. Note the marked difference in signal within the brainstem between the two patients (sagittal images, left), despite similar signal in the basal ganglia (axial images, right). (D) A significant correlation is demonstrated between apathy severity, measured by the LARS, and ¹²³I-ioflupane SPECT/CT signal in the DRN. Dashed lines indicate the 95% confidence interval of the best fit line.