Table 1.
Extract | Cytochrome P450 iso-enzymes 1 | ||||||||
---|---|---|---|---|---|---|---|---|---|
1A2 | 2A6 | 2B6 | 2C8 | 2C9 | 2C19 | 2D6 | 2E1 | 3A4 | |
18β-Glycyrrhetinic acid | + | + | + | ++ | + | + | + | + | ++ |
Glabridin | + | + | + | ++ | + | + | + | + | ++ |
Glycycoumarin | ++ | + | ++ | +++ | +++ | +++ | ++ | + | + |
Isoliquiritigen | + | + | + | +++ | +++ | + | + | ++ | ++ |
Licochalcone A | ++ | + | + | +++ | +++ | +++ | ++ | ++ | ++ |
Licoricidin | + | + | +++ | +++ | +++ | +++ | ++ | ++ | ++ |
1 + = weak inhibition, ++ = moderate inhibition and +++ = strong inhibition.