Figure 5.

Postsynaptic proteome interaction network showing the cluster structure for the “stable network”. A few large clusters with specific functionally related proteins could be detected: cl. 3 contains ribosomal proteins (red cluster at the bottom), cl. 4 contains metabolic enzymes (light green on the left), cl. 7 is enriched with actin-, myosin- and cytoskeleton remodeling-associated proteins (dark blue near the top), cl. 8 contains NADH-oxidoreductases (dark-red cluster on the right) and cl. 1 contains ATPases and voltage-dependent anion channels (light blue on the right). cl. 6 corresponds to key proteins involved in synaptic transmission and plasticity, including AMPA, NMDA receptors and MAGUK proteins (orange cluster at the top). Networks were visualized with Gephi.