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In dementia patients, weight and appetite impairment are due to multiple and reciprocal interconnections among body systems, with cognitive decline adding to the constitutive ageing process, rendering subjects vulnerable to malnutrition and frailty. T1R1: G protein-coupled Taste Receptor type 1 member 1; T1R3: G protein-coupled Taste Receptor type 1 member 3; GLP-1: Glucagon-Like Peptide-1; VEN: Von Economo neurons.
