Table 1.
JM1 virus pathogenesis in chick embryos and newborn mice.
| Inoculum | Organism | Route | Age | Mortality | Mortality at Day Post Infection (DPI) | Remarks |
|---|---|---|---|---|---|---|
| Mouse brain suspension, Neat | Swiss mice | intraperitoneal | 1 do | 8/8 | 4 | |
| Mouse brain suspension, Neat | Swiss mice | intracranial | 10 do | 8/8 | 3 | |
| Mouse brain suspension, Neat | Swiss mice | intraperitoneal | 10 do | 4 */8 | 6 | * Paralyzed Mice died on 7 dpi, Left leg paralysis noted in a survivor. |
| Mouse brain suspension, Neat | Swiss mice | intraperitoneal | 17 do | 1 */8 | 7 | * Paralyzed mouse died on 8 dpi. |
| Mouse brain suspension, Neat | Chicken | Allantoic | est. 8–10 do | 2/3 | 2, 3 | Hemorrhages on head, frank oozing of blood from skull, generalized edema, body hemorrhages. |
| Tissue Culture Fluid (<3 passages) | Chicken | Allantoic | est. 8–10 do | 1/7 | 6 | Hemorrhages on heart and liver. |
*: Mouse paralyzed prior to death.