Table 1.
[125I]TLQP-21 tissue distribution pattern in rats
| CPM | Relative tissue uptake | ||
|---|---|---|---|
| Organs | μg protein | g wet tissue* % | entire organ** % |
| Pancreas | 2.19±0.44 | 34.2±4.8 | 3.7 |
| Kidney | 1.22±0.12 | 27.3±3.0 | 6.4 |
| Spleen | 0.45±0.04 | 9.0±0.6 | 0.5 |
| Liver | 0.32±0.03 | 8.4±0.6 | 6.9 |
| Heart | 0.25±0.02 | 7.0±0.6 | 0.8 |
| Adrenal Gland | 0.35±0.02 | 6.8±0.7 | 0.03 |
| ScWAT | 0.28±0.03 | 1.5±0.1 | 4.4 |
| Tibialis anterior | 0.19±0.02 | 5.9±0.5 | 77 |
| Cerebrum | 0.07±0.02 | <0.5 | 0.1 |
| Cerebellum | 0.08±0.02 | <0.5 | |
| Hypothalamus | 0.06±0.01 | <0.5 | |
| Brain stem | 0.06±0.01 | <0.5 | |
*
CPM/tissue (g) CPM/all tissues (g) x 100%.
**
CP M/organ ÷ CPM/all organs x 100%.
scWAT, subcutaneous inguinal white adipose tissue. Organ weights are from in-house data of rats of the same breed. Total adipose tissue quantified by Rodent DEXA or from the published data for pancreas [Reaven et al., 1987], and kidney, spleen, liver, heart, adrenal gland and brain [Piao et al., 2013]. Skeletal muscle is assumed to be 40% of body weight [Holliday et al., 1967].