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. 2016 Jun 9;13(3):218–226. doi: 10.1007/s13770-016-9058-5

Fabrication and characterization of hydrocolloid dressing with silk fibroin nanoparticles for wound healing

Ok Joo Lee 1, Jung-Ho Kim 1, Bo Mi Moon 1, Janet Ren Chao 2, Jaeho Yoon 3, Hyung Woo Ju 1, Jung Min Lee 1, Hyun Jung Park 1, Dong Wook Kim 1, Seung Ju Kim 4, Hae Sang Park 5, Chan Hum Park 1,5,✉
PMCID: PMC6170831  PMID: 30603402

Abstract

Hydrocolloid dressings have been developed for many types of wound healing. In particular, dressing is a critical component in the successful recover of burn injuries, which causes a great number of people to not only suffer from physical but also psychological and economic anguish each year. Additionally, silk fibroin is the safest material for tissue engineering due to biocompatibility. In this study, we fabricated hydrocolloid dressings incorporating silk fibroin nanoparticles to enhance the efficacy of hydrocolloid dressing and then use this silk fibroin nanoparticle hydrocolloid dressing (SFNHD) in animal models to treat burn wounds. The structures and properties of SFNHD were characterized using tensile strength and Cell Counting Kit-8 assay. The results indicated the structural stability and the cellular biocompatibility of the hydrocolloid dressing suggesting that SFNHD can be applied to the treatment of wounds. To demonstrate the capacity of a silk fibroin hydrocolloid dressing to treat burn wounds, we compared SFNHD to gauze and Neoderm®, a commercially available dressing. This study clearly demonstrated accelerated wound healing with greater wound structural integrity and minimal wound size after treatment with SFNHD. These observations indicate that SFNHD may be an improvement upon current standard dressings such as Gauze and Neoderm® for burn wounds.

Keywords: Hydrocolloid dressings, Silk fibroin nanoparticles, Biocompatibility

Footnotes

These authors contributed equally to this work.

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