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. 2018 Apr 27;68(3):1057–1069. doi: 10.1002/hep.29888

Figure 5.

Figure 5

Bile flow and biliary BS output are reduced upon NTCP‐inhibition while phospholipid output is increased. (A‐B) Hepatic bile flow (μL/min/100g BW) determined at 10‐minute intervals during a 30‐minute period after gall bladder cannulation in DDC‐fed mice (A) and Atp8b1‐G308V mutant mice (B). (C‐D) Biliary bile salt output (nmol/min/100g BW) determined at 10‐minute intervals during a 30‐minute collection period in DDC‐fed mice (C) and Atp8b1‐G308V mutant mice (D). (E‐F) Correlation plot between biliary bile salt and phospholipid output in DDC‐fed mice (E) and Atp8b1‐G308V mutant mice (F) treated with vehicle (white squares) or myrcludex B (black squares). Data is from 3‐5 mice/group.