FIG 4.

Bioenergetic flux profiles of M. tuberculosis with AX-35 or Q203 treatment. The oxygen consumption rates of wild-type H37Rv, H37Rv ΔcydAB, and H37Rv Δcyd KO with a QcrB(A317V) mutation (Q203 resistance SNP) were measured at basal levels, then in the presence of (A) AX-35 (final concentration of 14 µM [100× MIC₅₀]) or (B) Q203 (final concentration of 0.3 µM [100× MIC₅₀]), and then at maximum capability with the depolarization of the bacterial membrane by the protonophore carbonyl cyanide m-chlorophenyl hydrazine (CCCP).