Figure 3. Pathways of top prioritized proteins.
(A) The Venn diagram showing the shared pathways between the significantly enriched (q-value <0.05) pathways of the top candidates (empirical p-value<0.01) prioritized by the addition of the M(-), M(IFNγ) and M(IL-4) co-abundance networks to the PPI network. (B) The hierarchically clustered condition-specific pathways (see Figure 3—figure supplement 1 for a full list). Darker shades of colors indicate a higher enrichment in terms of the negative logarithm of q-value.
Figure 3—source data 1. Source data for Figure 3: All enriched pathways of the top N (p<0.01) prioritized proteins.
elife-37059-fig3-data1.xlsx (290.7KB, xlsx)
Figure 3—figure supplement 1. The full list of hierarchically clustered condition-specific pathways.
Darker shades of colors indicate a higher enrichment in terms of the negative logarithm of q-value.
Figure 3—figure supplement 1—source data 1. The enrichment p-values of the condition-specific pathways shown in the clustered heatmap of Figure 3—figure supplement 1.
elife-37059-fig3-figsupp1-data1.xlsx (14.7KB, xlsx)
Figure 3—figure supplement 2. The network of significantly enriched pathways of the top-ranked (empirical p-value<0.01) candidates prioritized by the addition of the M(IFNγ) co-abundance network to the PPI network.
Node size indicates the significance of each pathway in –log(q-value) and edge thickness represents the overlap between the genes of the two pathways they connect, measured in terms of the Jaccard index.
Figure 3—figure supplement 3. The network of significantly enriched pathways of the top-ranked (empirical p-value<0.01) candidates prioritized by the addition of the M(IL-4) co-abundance network to the PPI network.
Node size indicates the significance of each pathway in –log(q-value) and edge thickness represents the overlap between the genes of the two pathways they connect, measured in terms of the Jaccard index.