Fig. 5.

Diazepam reverses the attenuation of VTA DA neuron activity induced by withdrawal from acute AMPH. Extracellular recordings of VTA DA neurons were conducted in SAL and AMPH-withdrawn rats following social behavior testing post-vehicle or DZ treatment (n = 7 per group). a In contrast to AMPH-withdrawn rats receiving vehicle, AMPH-withdrawn rats treated with DZ did not exhibit an attenuation of DA neuron activity and instead showed population activity similar to SAL animals treated with vehicle or DZ (p < 0.05). b An increase in firing rate was observed in the AMPH-W groups regardless of vehicle or DZ treatment (p < 0.01). c No effect of AMPH-W (p = 0.08) or DZ (p = 0.51) was found in the percentage of spikes in burst. *p < 0.05, **p < 0.01. Error bars indicate mean + SEM