Complex and invasive intravenous administration of biotherapeutics, typically conducted in clinic, contributes to the pressure on healthcare systems. Subcutaneous administration has been shown to be a safe and efficacious dosing alternative that is generally valued by both patients and healthcare professionals.

The development of fixed-dose subcutaneous formulations that are delivered independent of patient body weight, technologies that facilitate the injection of dosing volumes > 5 ml, and devices that allow self-administration outside of the hospital setting have all markedly contributed to shifting care to the home setting.

Many biotherapeutics are being investigated for combination therapy; subcutaneous administration could further simplify drug delivery with the development of fixed-dose combinations or ready-to-use devices that deliver two or more biotherapeutics via one single subcutaneous injection.