Abstract
Scientific evidences show a relationship between chronic inflammation and quality of life (QoL). This study verified the impaired quality of life, in different domains, associated with elevated inflammatory biomarkers levels, in older adults. Cross-sectional population-based study (SABE Study), including older adults (≥ 60 years-old). The inflammatory biomarkers used were uric acid, fibrinogen e C-reactive protein serum levels determined by using sensitive regular immunoassays (ELISA). QoL was assessed using the SF12 questionnaire. Socio-demographic information and health conditions were: sex, age and educational level; number of non-communicable diseases, self-reported conditions (chronic pains, hypertension, diabetes and cardiovascular disease), functional capacity, body mass index and waist circumference, respectively, identified using questionnaire and specific measures. Multiple logistic regression was used to analyze this association. From the 1.344 older adults, 1255 were eligible to be part of this study. There was no association of uric acid and fibrinogen with QoL. When we regarded the levels of CRP, men showed a higher average, being that older men (≥75 years) had a decrease in levels of CRP. Older adults with one or more chronic diseases, hypertension and BMI higher than 30kg/m2 presented low values in the physical domain of SF12 and were associated with high levels of CRP. The adjusted model showed a strong relationship with the worst ratings in physical domain of SF12 and high BMI values. The joint associations of physical domain of quality of life and inflammation in older adults have a significant effect in chronic inflammation.