Abstract
Frailty is a hallmark of vulnerability in older adults predisposed to adverse health outcomes, posing as a major threat to healthy aging. Community-based interventions targeting the pre-frail and frail elderly tend to show beneficial effects on frailty status. A growing body of evidence suggests that exercise interventions may be effective in enhancing physical function and performance. Evidence on the benefits of nutrition by itself is, however, inconclusive. A combined exercise and nutritional intervention appears to be more effective. More recently, multi-component interdisciplinary interventions that combine exercise, nutrition, cognitive training, and comprehensive geriatric assessment appear promising. To enhance our understanding of effective preventive interventions for frailty, larger scale clinical trials are needed. This will help to develop individually tailored prevention programs and evidence-based clinical practice guidelines, and to prioritize frailty prevention as one of the key policy agenda for healthy aging.