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. 2018 Nov;24(11):1443–1456. doi: 10.1261/rna.067132.118

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© 2018 Zhou et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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FIGURE 5. — Age-dependent circRNA expression. (A) Relationship between age and overall circRNA abundance across the 11 tissue types. (B) Distribution of the correlation coefficients (ρ) between age and the expression of linear/circular transcripts in the brain. The ρ values were calculated with Spearman's rank correlation test. (C) Paired comparisons of ρ between the circRNAs that accumulated with age (ρ > 0.7) and their linear counterparts in the brain. (D) Top 10 GOBP terms associated with the circRNAs that accumulated with age in the brain. The P-values were calculated with Fisher's exact test. The vertical dashed line indicates the significance level of α = 0.05.