Fig. 1.

Hundreds of germ cell-specific genes are widely expressed in tumors. Shown here as hierarchical clustering of the average expression per tumor group (Euclidean distance, ward linkage). These germ cell cancer genes (GC-genes) divide tumors in two main groups, mainly based on GC-gene cluster 3, containing genes involved in mitotic and meiotic metaphase regulation. Gene expression levels are indicated by a Z-score-dependent color, where blue and red represent low and high expression, respectively