Table 1.
Clinical profiles of the VL patients treated with miltefosine and genome sequencing summary.
| Isolate ID | Locationa | Treatment lengthb (days) | Clinical outcome | Presence of MSLc | Coverage fold | Mappingd (%) |
|---|---|---|---|---|---|---|
| MHOM/BR/06/MA01A | Paraibano-MA | 42 | Cure | + | 66·2 | 98·89 |
| MHOM/BR/05/MA02A | Codó-MA | 42 | Cure | +/− | 66·8 | 99·06 |
| MHOM/BR/06/MA03A | Timon-MA | 42 | Cure | + | 91·2 | 98·72 |
| MHOM/BR/06/MA04A | Codó-MA | 42 | Cure | − | 46·9 | 98·85 |
| MHOM/BR/05/MA05A | Timon-MA | 42 | Cure | +/− | 41·3 | 98·98 |
| MHOM/BR/06/MA07A | Caxias-MA | 42 | Relapse | − | 27·1 | 98·94 |
| MHOM/BR/05/MG11A | Montes Claros-MG | 28 | Relapse | − | 75·1 | 98·67 |
| MHOM/BR/05/MG12A | Montes Claros-MG | 28 | Cure | − | 43·4 | 98·87 |
| MHOM/BR/05/MG13A | São Francisco-MG | 28 | Relapse | − | 47·5 | 99·15 |
| MHOM/BR/05/MG14A | Montes Claros-MG | 28 | Cure | + | 57·7 | 98·99 |
| MHOM/BR/05/MG15A | Porteirinha-MG | 28 | Relapse | − | 64·5 | 98·74 |
| MHOM/BR/05/MG16A | São Francisco-MG | 28 | Relapse | − | 83·5 | 98·99 |
| MHOM/BR/05/MG17A | Montes Claros-MG | 28 | Relapse | − | 65·1 | 98·83 |
| MHOM/BR/05/MG18A | Montes Claros-MG | 28 | Relapse | − | 48·6 | 98·54 |
| MHOM/BR/05/MG19A | Catuni-MG | 28 | Cure | − | 56·3 | 98·44 |
| MHOM/BR/06/PI01A | José de Freitas-PI | 42 | Relapse | − | 92·7 | 98·95 |
| MHOM/BR/06/PI02A | Valença do Piauí-PI | 42 | Relapse | − | 60·0 | 98·63 |
| MHOM/BR/06/PI03A | Cabeceiras-PI | 42 | Relapse | − | 65·3 | 98·57 |
| MHOM/BR/05/PI04A | Valença do Piauí-PI | 42 | Cure | +/− | 46·7 | 98·82 |
| MHOM/BR/06/PI05A | Valença do Piauí-PI | 42 | Cure | +/− | 41·3 | 99·02 |
| MHOM/BR/06/PI07A | Piripiri-PI | 42 | Cure | + | 47·1 | 99·03 |
| MHOM/BR/05/PI08A | Altos-PI | 42 | Cure | +/− | 46·1 | 99·07 |
| MHOM/BR/05/PI09A | Nova Santa Rita-PI | 42 | Cure | +/− | 57·8 | 99·01 |
| MHOM/BR/06/PI10A | Teresina-PI | 42 | Cure | +/− | 76·9 | 98·63 |
| MHOM/BR/06/PI11A | José de Freitas-PI | 42 | Relapse | − | 42·2 | 98·94 |
| MHOM/BR/05/PI12A | Lima Campos-PI | 42 | Relapse | + | 58·6 | 98.68 |
a
City-States in Brazil where the L. infantum isolates were collected: MA, Maranhão; MG, Minas Gerais; PI, Piauí.
b
Miltefosine therapy schedule. Patients received about 2·5 mg/kg/day.
c
Genotyping of L. infantum isolates : MSL+, homogeneous population for presence of MSL; MSL−, homogeneous population for absence of MSL; MSL+/−, heterogeneous population for presence of MSL.
d
Mapping of sequences reads from L. infantum isolates to L. infantum JPCM5 reference genome.