Table 2.
Multivariable association of the radiomics score and clinicopathological characteristics with disease-free survival and overall survival in the training cohort.
| Variables | Disease-free survival |
Overall survival |
||
|---|---|---|---|---|
| HR (95%CI) | p | HR (95%CI) | p | |
| Radiomics score | 1.744 (1.346–2.261) | <0.0001 | 3.308 (1.752–3.040) | <0.0001 |
| Differentiation status | 0.008 | 0.019 | ||
| Well | Reference | Reference | ||
| Moderate | 2.242 (1.037–4.850) | 0.040 | 2.150 (0.890–5.195) | 0.089 |
| Poor or undifferentiation | 2.835 (1.330–6.044) | 0.007 | 2.904 (1.213–6.954) | 0.017 |
| CA199 (elevated vs. nomal) | 1.829 (1.243–2.692) | 0.002 | 1.963 (1.313–2.934) | 0.001 |
| Depth of invasion | 0.0005 | 0.011 | ||
| T1 | Reference | Reference | ||
| T2 | 1.625 (0.296–8.923) | 0.576 | 1.546 (0.281–8.497) | 0.617 |
| T3 | 5.052 (0.942–27.102) | 0.059 | 4.971 (0.930–26.578) | 0.061 |
| T4a | 3.010 (0.703–12.884) | 0.137 | 2.472 (0.571–10.704) | 0.226 |
| T4b | 6.269 (1.425–27.579) | 0.015 | 4.279 (0.968–18.927) | 0.055 |
| Lymph node metastasis | <0.0001 | 0.0002 | ||
| N0 | Reference | Reference | ||
| N1 | 0.951 (0.478–1.890) | 0.886 | 0.919 (0.441–1.918) | 0.822 |
| N2 | 0.952 (0.517–1.751) | 0.873 | 0.947 (0.494–1.817) | 0.871 |
| N3 | 3.806 (2.110–6.866) | <0.0001 | 2.124 (1.126–4.007) | 0.020 |
| Distant metastasis (yes vs. no) | 6.240 (3.976–9.793) | <0.0001 | 3.518 (2.322–5.330) | <0.0001 |