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. 2018 Oct 30;8:15924. doi: 10.1038/s41598-018-34061-y

Author Correction: Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation

Yanqiong Zhang 1, Ming Bai 2, Bo Zhang 3, Chunfang Liu 1, Qiuyan Guo 1, Yanqun Sun 1, Danhua Wang 1, Chao Wang 1, Yini Jiang 1, Na Lin 1,, Shao Li 1,2,
PMCID: PMC6207787  PMID: 30375403

Correction to: Scientific Reports 10.1038/srep09463, published online 30 March 2015

This Article contains errors.

In Figure 1,

“Collagen-induced arthritis (CIA) mouse model”

should read:

“Collagen-induced arthritis (CIA) rat model”

In addition, in Figure 4A the panel showing the inflamed paw of the CIA group is incorrect.

Furthermore, the legend of Figure 4 contains an error where,

‘mice’

should read:

‘rats’

The correct Figure 4 and its accompanying legend appear below as Figure 1.

Figure 1.

Figure 1

Effects of Wu-tou decoction (WTD) on severity of arthritis in collagen-induced arthritis (CIA) rats. (A) macroscopic evidence of arthritis such as erythema or swelling was markedly observed in vehicle-treated CIA rats, while dose of 3.8 g/(kg·day) WTD significantly attenuated arthritis severity in CIA rats; (B) Doses of 0.95~3.8 g/(kg·day) WTD significantly decreased the mean arthritis score in a dose-dependent manner compared with vehicle-treated CIA rats; (C) Doses of 0.95~3.8 g/(kg·day) WTD significantly decreased the arthritis incidence in a dose-dependent manner compared with vehicle-treated CIA rats; (D) Doses of 0.95~3.8 g/(kg·day) WTD significantly decreased the percentage of arthritis limbs in a dose-dependent manner compared with vehicle-treated CIA rats; (E) Doses of 0.95~3.8 g/(kg·day) WTD significantly increased the time of arthritis first appeared compared with vehicle-treated CIA rats. Data are represented as the mean±S.D. (n=12). ‘#’, P<0.05, comparison with the normal control. ‘*’, ‘**’, and ‘***’, P<0.05, P<0.01, and P<0.001, respectively, comparison with the vehicle control.

Finally, in the Methods section under the subheading ‘Treatment and groups’,

“The dosage selection for WTD [3.8 μg/(kg·day)] was nearly equivalent to RA patient dosage daily (42 g/person/day).”

should read:

“The dosage selection for WTD [3.8 g/(kg·day)] was nearly equivalent to RA patient dosage daily (42 g/person/day).”

Contributor Information

Na Lin, Email: linna888@163.com.

Shao Li, Email: shaoli@mail.tsinghua.edu.cn.


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