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. 2018 Jul 2;21(4):861–871. doi: 10.1007/s10456-018-9631-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Fibroblasts organization in the microvessels. a Live cells were imaged, and segments of the central chambers on day 7 are shown. HUVECs are shown in green, and NL-FBs are shown in red. In untreated chips, NL-FBs appeared to wrap around the endothelial vessels, whereas treatment with 50 nM nintedanib caused NL-FBs to localize away from endothelial lumens. Nintedanib treatment started on day 1. Scale bar: 200 µm. b Colocalized areas were defined as regions where fibroblasts overlapped endothelial cells. Nintedanib decreased fibroblast coverage around endothelial cells and significantly decreased the amount of colocalized area