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. 2018 Oct 30;9(5):e01871-18. doi: 10.1128/mBio.01871-18

FIG 4.

FIG 4

Multiplication kinetics of the IC at an MOI of 0.1 in A549 cells. (A) Parental IC-derived Asibi and 17D-204 viruses. (B) Structural chimeric viruses. (C and D) NS mutant viruses. Multiplication kinetics of IC-derived Asibi and 17D-204 viruses are statistically different at 24, 36, and 48 hpi as determined by a Student’s t test. The introduction of neither NS2B-L109 nor NS4B-M95I into the 17D-204 backbone altered the multiplication kinetics, while introduction of either NS2B-I109L or NS4B-I95M into the Asibi backbone did alter the multiplication kinetics. Chimeric and mutant viruses were compared to parental IC-derived virus using one-way ANOVA test, followed by Tukey’s multiple-comparison test. Statistical significance is indicated as follows: ns, not significant (P value = 0.12), *, P = 0.033; **, P = 0.002; ***, P < 0.001 (GraphPad Prism, version 7.0a).