TABLE 1.

Recrudescence time of active B. mandrillaris following drug treatment

Treatment	Mean no. of days for host cell clearance ± SE
Vehicle only
0.28% (vol/vol) DMSO	1.33 ± 0.33
1.12% (vol/vol) water	1.67 ± 0.67
Nitroxoline (in DMSO)
3.5 µM	15.33 ± 0.67
7 µM	19 ± 0.58
14 µM	22 ± 2.08
28 µM	NRTa
Pentamidine isethionate (in water)
3.5 µM	1.33 ± 0.33
7 µM	7 ± 1.15
14 µM	13 ± 2.51
28 µM	15.33 ± 2.56
56 µM	16 ± 2
Miltefosine
28 µM	1.5 ± 0.33
56 µM	3.5 ± 2.64
84 µM	>28b
112 µM	NRTa

^aNRT, no recovery of trophozoites or host cell destruction observed through 28 days.

^bIncomplete recovery of trophozoites and destruction of host cells on day 28.