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. 2018 Oct 2;10(10):1401. doi: 10.3390/nu10101401

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PM-induced gene expression changes in liver tissues of zebrafish. (A–C) PM effects on gene expression related to beta-oxidation in zebrafish. PM up-regulated pparab (A) and acox1 (B) expressions, in contrast to the downregulation of acadm (C). (D–F) PM effects on gene expression related to lipogenesis in zebrafish. PM suppressed DIO-induced upregulation of pparg (D) and cebpa (E), not of srebf1. * p < 0.05, ** p < 0.01. n = 5, error bars indicate SD. pparab: peroxisome proliferator-activated receptor alpha b; gapdh: glyceraldehyde-3-phosphate dehydrogenase; acox1: acyl-CoA oxidase 1, palmitoyl; cebpa: CCAAT/enhancer-binding protein alpha; acadm: acyl-CoA dehydrogenase, C-4 to C-12 straight chain; srebf1: sterol element binding transcription factor 1.