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. 2018 Oct 2;10(10):1399. doi: 10.3390/nu10101399

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PG102 suppresses hyperproliferation of keratinocytes through STAT3 signaling. (A) WST-1 cell proliferation assay in HaCaT cells treated with M5 and PG102 for 24 h and 48 h (n = 3). (B) PG102 was treated to M5-stimulated HaCaT cells for 30 min and Western blot analysis was performed. (C) Densitometry results of Western blot. The means of three independent experiments are shown. p-STAT3 (Y705), phospho-signal transducer and activator of transcription 3 (Tyr705). p-STAT3 (S727), phospho-signal transducer and activator of transcription 3 (phospho S727). ^## p < 0.01, ^#### p < 0.0001 versus Control group; * p < 0.05, ** p < 0.01 versus M5-only treated group. The data are shown as the mean ± standard error (SD).

PG102 suppresses hyperproliferation of keratinocytes through STAT3 signaling. (A) WST-1 cell proliferation assay in HaCaT cells treated with M5 and PG102 for 24 h and 48 h (n = 3). (B) PG102 was treated to M5-stimulated HaCaT cells for 30 min and Western blot analysis was performed. (C) Densitometry results of Western blot. The means of three independent experiments are shown. p-STAT3 (Y705), phospho-signal transducer and activator of transcription 3 (Tyr705). p-STAT3 (S727), phospho-signal transducer and activator of transcription 3 (phospho S727). ^## p < 0.01, ^#### p < 0.0001 versus Control group; * p < 0.05, ** p < 0.01 versus M5-only treated group. The data are shown as the mean ± standard error (SD).