Table 1.

Proposed unifying nomenclature and examples of immunodeficiency-associated LPDs

3-Part unifying nomenclature
Name of lesion	Viral status	Specific immunodeficiency setting
B-cell hyperplasia (eg, plasmacytic hyperplasia)	eg, EBV+/−, HHV8+/−	eg, Posttransplant (solid organ), iatrogenic (methotrexate), immune senescence
Polymorphic B-cell lymphoproliferations (eg, mucocutaneous ulcer)
Lymphoma (WHO terminology) (eg, diffuse large B-cell lymphoma, Anaplastic large cell lymphoma, ALK−)

Examples of diagnostic labels
Proposed unifying nomenclature	WHO 2016 nomenclature
Plasmacytic hyperplasia, EBV+, posttransplant (solid organ)	Plasmacytic hyperplasia, nondestructive posttransplant LPD
Polymorphic B-LPD, EBV+, iatrogenic (methotrexate)	Polymorphic LPD resembling polymorphic posttransplant LPD
Mucocutaneous ulcer, EBV+, primary immunodeficiency (CHARGE syndrome)	EBV+ mucocutaneous ulcer
Diffuse large B-cell lymphoma, EBV−, HIV infection	Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma, T-cell/histiocyte-rich, EBV+, immune senescence	EBV+ diffuse large B-cell lymphoma
Primary effusion lymphoma, HHV8+, EBV+, HIV infection	Primary effusion lymphoma