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. 2018 Oct 31;5(5):ENEURO.0272-18.2018. doi: 10.1523/ENEURO.0272-18.2018

Figure 5.

Figure 5.

BA GABA neuron stimulation inhibits BA pyramidal neurons. A, mIPSCs in BA pyramidal neurons from GADCre(+)/hM3Dq mice (Vhold = −70 mV). Traces show mIPSCs before (baseline) and after application of CNO (10 μm), and mIPSC sensitivity to the GABAAR antagonist PTX (100 μm). B, Impact of CNO/hM3Dq-mediated activation of BA GABA neurons on mIPSC frequency in BA pyramidal neurons (t(6)=2.6, *p = 0.400). Post-CNO measures were normalized to baseline for each recording because of significant cell-to-cell variability in mIPSC activity (n = 7 experiments). C, Impact of CNO/hM3Dq-mediated activation of BA GABA neurons on mIPSC amplitude in BA pyramidal neurons (t(6)=4.1, **p = 0.006); post-CNO measures were normalized to baseline values for each recording (n = 7 experiments). D, Impact of CNO/hM3Dq-mediated activation of BA GABA neurons on rheobase in BA pyramidal neurons, at baseline and after CNO application (t(5)=4.8, **p = 0.005; n = 6 experiments).