. 2018 Aug 14;23(8):2033. doi: 10.3390/molecules23082033
© 2018 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Scheme 1.
Synthesis of compounds 4a–4u. (a): (C2H5)3N/THF/0 °C then rt; (b) acetone/reflux.
| Comp. |
|
R | Comp. |
|
R |
| 4a | Piperazinyl | 4-(2-(dimethylamino)ethyl | 4l | Piperazinyl | 4-cyclohexyl |
| 4b | Piperazinyl | 4-(3-(dimethylamino)propyl | 4m | Piperazinyl | 4-benzhydryl |
| 4c | Piperazinyl | 4-ethyl | 4n | Piperazinyl | 4-[4-(trifluoromethyl)benzyl] |
| 4d | Piperazinyl | 4-(4-nitrophenyl) | 4o | Piperazinyl | 4-(4-methylbenzyl) |
| 4e | Piperazinyl | 4-(2-hydroxyethyl) | 4p | Piperazinyl | 4-(4-fluorophenyl) |
| 4f | Piperazinyl | 4-phenyl | 4q | Piperazinyl | 4-(2-furoyl) |
| 4g | Piperazinyl | 4-methyl | 4r | Morpholinyl | - |
| 4h | Piperazinyl | 4-(4-methoxyphenyl) | 4s | Piperidinyl | - |
| 4i | Piperazinyl | 4-(4-chlorophenyl) | 4t | Piperidinyl | 2-methyl |
| 4j | Piperazinyl | 4-(pyrimidin-2-yl) | 4u | Piperidinyl | 4-benzyl |
| 4k | Piperazinyl | 4-benzyl |