Table 4.
Permeability parameters of ciprofloxacin through Caco-2 cells monolayer in AP-BL and BL-AP directions (mean ± SD, n = 6).
| Formulation | AP-BL Direction | BL-AP Direction | ||
|---|---|---|---|---|
| Q4% | P (cm/s) × 104 | Q4% | P (cm/s) × 104 | |
| Optimized formulation | 72 ± 1.9 | 2.40 ± 0.19 | 84.6 ± 5.1 | 2.89 ± 0.22 |
| Optimized formulation without ginsenoside | 58.3 ± 1.3 | 1.9 ± 0.16 | 79.2 ± 5.6 | 2.77 ± 0.28 |
| Ciprofloxacin 0.14 mg/mL + ginsenoside 0.02 mg/mL (control 1) | 47.2 ± 4.2 | 1.27 ± 0.11 | 65.5 ± 7.1 | 2.13 ± 0.15 |
| Ciprofloxacin 0.14 mg/mL + ginsenoside 0.08 mg/mL (control 2) | 60.7 ± 2.8 | 2.05 ± 0.14 | 67.7 ± 8.1 | 2.22 ± 0.32 |
| Ciprofloxacin 0.14 mg/mL + ginsenoside 0.23 mg/mL (control 3) | 77.3 ± 2.5 | 2.67 ± 014 | 64.7 ± 10.2 | 2.28 ± 0.3 |