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. 2018 Oct 17;23(10):2668. doi: 10.3390/molecules23102668

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of bergenin on immunoglobulin levels and immune cell activity in the Cy-treated mice. (A) Serum IgG levels; (B) Serum IgM levels; (C) Peritoneal macrophage phagocytosis; (D) Splenocyte proliferation induced by Con A and LPS; (E) Splenic NK and CTL cytotoxic activities. NC: normal control group, dosed with saline; MC: model control group, challenged with cyclophosphamide; Be-L: challenged with Cy and treated with 5 mg/kg/day bergenin; Be-M: challenged with Cy and treated with 10 mg/kg/day bergenin; Be-H: challenged with Cy and treated with 20 mg/kg/day bergenin. Data are expressed as mean ± SD (n = 8). ^## p < 0.01 vs. the NC group, * p < 0.05 and ** p < 0.01 vs. the MC group.