Table 4.
Antifungal activity of compounds 6–20. MIC and MFC are expressed in µg/mL 1.
| Comp. |
C. albicans ATCC 10231 |
A. fumigatus ATCC 46645 |
T. rubrum FF5 |
M. canis FF1 |
E. floccosum FF9 |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC | MFC | MIC | MFC | MIC | MFC | MIC | MFC | MIC | MFC | |
| 6 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 7 | >128 | >128 | >128 | >128 | >128 | >128 | ND | ND | ND | ND |
| 8 | >128 | >128 | >128 | >128 | ≥128 | >128 | >128 | >128 | 128 | 128 |
| 9 | >128 | >128 | >128 | >128 | ≥128 | >128 | ≥128 | >128 | ≥128 | >128 |
| 10 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 11 | >32 | > 32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 12 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 13 | >128 | >128 | >128 | >128 | >128 | >128 | ND | ND | ND | ND |
| 14 | >128 | >128 | >128 | >128 | >128 | >128 | ND | ND | ND | ND |
| 15 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 16 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 17 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 18 2 | >128 | >128 | >128 | >128 | 8 | 8 | 8 | 8 | 4 | 4 |
| 19 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
| 20 | >32 | >32 | >32 | >32 | >32 | >32 | ND | ND | ND | ND |
1 MIC—minimum inhibitory concentration; MFC—minimum fungicidal concentration; 2 Synergy with fluconazole.