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. 2018 Aug 2;23(8):1925. doi: 10.3390/molecules23081925

Figure 2.

Figure 2

Representative MRM chromatograms of corydaline (I), dehydrocorydaline (II), tetrahydropalmatine (III), protopine (IV), palmatine (V), tetrahydroberberine (VI), columbamine (VII), berberine (VIII), berberrubine (IX), coptisine (X) and theophyline (I.S.) in the beagle dog plasma: (1) drug-free beagle dog plasma sample; (2) A beagle dog plasma sample taken 0.75 h after administration of 0.150 g/kg Yuanhuzhitong Tablets; (3) A beagle dog plasma sample taken 0.75 h after administration of 0.048 g/kg C. yanhusuo extraction; (4) LLOQ sample (10 alkaloids and I.S. in blank plasma).