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. 2018 Oct 8;23(10):2568. doi: 10.3390/molecules23102568

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Compound 2 ameliorate TGF-β1-induced myofibroblast differentiation in alveolar epithelial A549 cells. A549 cells were treated with TGF-β1 (2 ng/mL) and compound 2 for 48 h. (A) Cytotoxicity of compound 2 in A549 cells was measured by WST-1 assay at 48h. Compound 2 was treated to A549 cells. (B) The protein expression of α-SMA and N-cadherin was analyzed by western blot. (C) Expression of collagen (Col1A1) and fibronectin was analyzed by qPCR-analysis. All the assays were performed in triplicate, and the data are shown as the mean values ± S.D. Values that are significantly different from the control are indicated by ^### p < 0.001, and values that are significantly different from the TGF-β1-treated group are indicated by *** p < 0.001.