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. 2018 Sep 8;23(9):2298. doi: 10.3390/molecules23092298

Figure 1.

Figure 1

Berberine (BBR) attenuated intestinal adenoma progress in Apc min/+ mice. (A) Representative macroscopic appearance of the small intestine (proximal) from wild type, Apc min/+, and BBR treated Apc min/+ mice. (B) Representative hematoxylin and eosin (HE) staining histological sections in the small intestine (proximal) in different groups: top panel: bar = 500 μm (100 μm × 5); bottom panel: bar = 250 μm (50 μm × 5). (C-1) Changes in body weight; (C-2) changes in tumor number; and (C-3) changes in tumor load in the small intestines of different groups. Control: wild type mice fed with a standard diet; model: Apc min/+ mice fed with a high fat diet; BBR: Apc min/+ mice fed with a high fat diet supplemented with BBR. The data are expressed as means ± standard errors. * represents p < 0.05 compared with the Model group.