In the article, “Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain,” by Cameron Rink, Surya Gnyawali, Richard Stewart, Seth Teplitsky, Hallie Harris, Sashwati Roy, Chandan K. Sen, and Savita Khanna, in FASEB J. April 2017 31: 1709–1718 (doi: 10.1096/fj.201601033R), there are editing errors in the last sentence of the abstract and the last paragraph of the article.
The correct last sentence of the abstract is as follows:
Taken together, our results support a new paradigm that GOT enables metabolism of otherwise neurotoxic extracellular Glu through a truncated tricarboxylic acid cycle under hypoglycemic conditions.
The correct last paragraph of the article is as follows:
Taken together, the findings of this study pave the way for a new paradigm suggesting that the functional significance of glutamate at the stroke site is switched by GOT from being a neurotoxic inducer of cell death to metabolic fuel that sustains neural tissue in the face of stroke-induced hypoglycemia. Importantly, this paradigm recognizes the therapeutic potential to target GOT for improved neurotoxic glutamate clearance and anaplerotic flux of TCA cycle intermediates in the hypoglycemic, stroke-affected brain.
This information has been revised online.
DOI: 10.1096/fj.201601033RERR