Table 1. Oxtr DNA methylation in the nucleus accumbens and in whole blood is negatively associated with Oxtr gene expression in the nucleus accumbens.

All methylation sites significantly negatively load onto the single CpG site component, indicating a significant negative association between Oxtr methylation and Oxtr expression in Nacc. In a separate analysis, all methylation sites significantly negatively load onto the single CpG site component, indicating a significant negative association between Oxtr methylation in whole blood and Oxtr expression in Nacc. Loadings, regression coefficients, and jackknife approximate t tests of regression coefficients for each model are listed in Table 1.

Model	Site	Loading	Estimate	Std. Error	Df	t value	p value
Nucleus Accumbens	934_1	−0.364	−3.10E-04	1.09E-04	25	−2.84	0.009
	934_2	−0.567	−4.29E-04	1.67E-04	25	−2.57	0.017
	924	−0.56	−5.22E-04	1.62E-04	25	−3.22	0.004
	901	−0.489	−4.36E-04	8.89E-05	25	−4.91	<.0001
Whole Blood	934_1	−0.599	−4.52E-04	1.71E-04	25	−2.64	0.014
	934_2	−0.515	−4.04E-04	1.61E-04	25	−2.52	0.019
	924	−0.499	−3.53E-04	1.45E-04	25	−2.43	0.022
	901	−0.367	−2.10E-04	1.04E-04	25	−2.03	0.053