Table 9.

Acute effects of benzo[a]pyrene on DNA damage (DNA content of comet tail, %) of various organs (mean ± SD, n = 100 cells).

Group	Time	Liver	Lung	Kidney	Stomach	Brain
Control	24	0.48 ± 0.19	0.41 ± 0.11	0.56 ± 0.09	0.79 ± 0.17	0.51 ± 0.26
12.5 mg/kg	24	5.72 ± 1.72c	3.43 ± 0.34c	6.21 ± 1.61c	2.96 ± 0.18c	4.34 ± 1.22c
25 mg/kg	24	6.54 ± 2.04c	5.65 ± 1.12c	8.33 ± 1.55c	4.35 ± 0.53c	6.28 ± 0.89c
50 mg/kg	24	11.95 ± 1.55c	9.75 ± 2.10c	11.89 ± 4.83c	6.23 ± 0.34c	9.14 ± 5.09c
100 mg/kg	24	12.13 ± 1.34c	10.55 ± 1.32c	12.32 ± 2.57c	9.02 ± 0.54c	10.23 ± 1.52c
Control	48	0.45 ± 0.16	0.38 ± 0.12	0.53 ± 0.07	0.77 ± 0.18c	0.48 ± 0.24c
12.5 mg/kg	48	4.43 ± 2.90c	3.37 ± 1.95c	4.22 ± 2.44c	2.42 ± 0.23c	3.56 ± 1.17c
25 mg/kg	48	5.94 ± 3.31c	4.05 ± 0.16c	8.01 ± 2.19c	3.85 ± 0.32c	5.80 ± 1.72c
50 mg/kg	48	9.12 ± 1.52c	7.93 ± 2.77c	7.16 ± 3.49c	4.85 ± 0.37c	8.45 ± 1.45c
100 mg/kg	48	10.31 ± 1.85c	9.65 ± 1.25c	10.22 ± 2.52c	7.21 ± 0.62c	8.85 ± 1.36c
Control	72	0.43 ± 0.17	0.37 ± 0.12	0.50 ± 0.07	0.76 ± 0.17c	0.47 ± 0.22
12.5 mg/kg	72	3.14 ± 1.50c	2.83 ± 1.62c	3.13 ± 1.35c	1.21 ± 0.18c	3.14 ± 1.76c
25 mg/kg	72	7.38 ± 1.26c	3.24 ± 0.11c	3.98 ± 1.82c	2.14 ± 0.23c	4.78 ± 2.12c
50 mg/kg	72	7.68 ± 2.64c	6.93 ± 2.67c	5.70 ± 2.32c	3.51 ± 0.26c	7.35 ± 2.07c
100 mg/kg	72	8.00 ± 4.50c	8.49 ± 2.44c	6.23 ± 2.12c	5.27 ± 0.36c	7.78 ± 1.23c
Control FPG	24	0.52 ± 0.12	0.44 ± 0.09	0.58 ± 0.10	0.83 ± 0.16	0.54 ± 0.21
12.5 mg/kg FPG	24	8.06 ± 1.83c	5.14 ± 0.42c	9.16 ± 1.83c	4.48 ± 0.35c	6.35 ± 1.27c
25 mg/kg FPG	24	9.56 ± 2.13c	7.35 ± 1.26c	11.73 ± 2.14c	6.24 ± 0.75c	9.11 ± 0.96c
50 mg/kg FPG	24	14.82 ± 1.67c	11.63 ± 2.26c	13.75 ± 3.21c	7.32 ± 0.46c	11.21 ± 3.12c
100 mg/kg FPG	24	16.15 ± 1.42c	12.62 ± 1.51c	16.35 ± 2.64c	10.91 ± 0.82c	12.11 ± 1.83c

^cP < 0.001 between the corresponding control and B[a]P treatment groups.