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. 2018 Nov 12;7:F1000 Faculty Rev-1781. [Version 1] doi: 10.12688/f1000research.15788.1

Figure 1. Progression and severity profiles in cerebellar ataxias by underlying etiology.

Figure 1.

Multisystem atrophy (MSA) is a rapidly progressing non-monogenic alpha-synucleinopathy. It is the most severe of these diseases, followed by polyglutamine (polyQ) spinocerebellar ataxias (SCAs), such as ATXN1/SCA1, ATXN2/SCA2, ATXN3/SCA3, CACNA1A/SCA6, ATXN7/SCA7, TBP/SCA17, and ATN1/DRPLA. Very different profiles are present in the forms because of missense mutations in channel genes ( CACNA1A, KCND3, KCNC3, and KCNA1).