TABLE 6.
Mutations detected in DNA gyrase (gyrA and gyrB genes) and topoisomerase IV (parC and parE genes) individually, and combined mutation profiles based on them
| Gene | Mutation | No. of mutations |
Mutation combination (profile) | No. of mutation profiles |
|---|---|---|---|---|
| gyrA | D538N | 352 | gyrA-D538N, gyrA-S83F | 179 |
| S83F | 299 | gyrA-D538N, gyrA-S83Y | 120 | |
| S83Y | 125 | gyrA-S83F | 66 | |
| D87N | 30 | gyrA-S83F, parE-A364V | 26 | |
| N529S | 17 | parE-A364V | 18 | |
| D87G | 11 | gyrA-N529S, gyrB-S464F | 17 | |
| D87Y | 4 | gyrA-D87N, parE-A364V | 15 | |
| A119E | 1 | gyrA-D538N, gyrA-D87N | 12 | |
| D87A | 1 | gyrA-D538N, gyrA-S83F, parE-T447A | 9 | |
| gyrB | S464F | 21 | gyrA-D538N | 8 |
| S464Y | 10 | gyrA-D538N, gyrA-D87G, gyrA-S83F, parC-E84K | 8 | |
| parC | E84K | 10 | gyrB-S464Y | 8 |
| S80R | 2 | gyrB-S464F | 3 | |
| D69A | 2 | gyrA-D538N, gyrA-D87Y | 2 | |
| T620M | 1 | gyrB-S464Y, parE-A364V | 2 | |
| E84G | 1 | gyrA-D87Y | 2 | |
| S80I | 1 | gyrA-S83Y, parC-D69A, parE-A364V | 2 | |
| parE | A364V | 69 | gyrA-D538N, gyrA-S83F, parE-L416F | 2 |
| T447A | 9 | gyrA-D87N, parE-A364V, parE-S339L | 2 | |
| L416F | 2 | gyrA-D538N, gyrA-S83Y, parE-A365S | 2 | |
| S339L | 2 | gyrA-D538N, gyrA-S83F, parC-E84K | 2 | |
| A365S | 2 | Other combination pattern (one isolate for each) | 13 | |
| L502F | 1 | No mutation | 18 | |
| E460K | 1 | |||
| Total | 536 |