Industrial Biotransformations. By Liese, Andreas / Seelbach, Karsten / Wandrey, Christian. Wiley-VCH, Weinheim , 2000. Pages: 423, Hardcover. Price: 213.19 DM / 109.- EUR / 189.- SFR. ISBN: ISBN 3-527-30094-5

Industrial Biotransformations - a user-friendly and application-oriented up-to-date overview of one-step biotransformations of industrial importance.

The data conferring each process is arranged in a convenient format to survey so that the processes can easily be compared. Each set of data is accompanied by key literature citations. As far as flow sheets of the processes are available, these are given reduced to their significant elements. An extensive index classified by substrates, products, enzymes, and companies provides direct access to each process organized in the order of enzyme classes. The reader will find all significant parameters characterizing the biotransformation itself and the process.

Data collection. Structured description of processes according to the following scheme:

• Product

• Reaction Scheme

• Reaction Conditions

• Flow Scheme

• Process Parameters

• Product Application

• Remarks

• References

Table of Contents:

• 1Introduction 1
• 2
  History of Industrial Biotransformations -- Dreams and Realities 3

  • 2.1
    From the "flower of vinegar" to the recombinant E. coli -- The history of microbial biotransformations 3
  • 2.2
    From gastric juice to SweetzymeT -- The history of enzymatic biotransformations 11
  • 2.3
    Advantages of biotransformations over classical chemistry 25

    • References 27
• 3
  Enzyme Classification 31

  • 3.1
    The Enzyme Nomenclature 31
  • 3.2
    The Enzyme Classes 33

    • EC 1 Oxidoreductases 34
    • EC 2 Transferases 39
    • EC 3 Hydrolases 43
    • EC 4 Lyases 48
    • EC 5 Isomerases 51
    • EC 6 Ligases 54
    • References 56
• 4
  Basics of Bioreaction Engineering 57

  • 4.1
    Definitions 58
  • 4.2
    Biosynthesis and immobilization of biocatalysts 64
  • 4.3
    Characteristics of the different enzyme classes 79
  • 4.4
    Kinetics 83
  • 4.5
    Basic reactor types and their mode of operation 86

    • References 90
• 5
  Processes 93

  • (Selection)

• Alcohol dehydrogenase Rhodococcus erythropolis 103

• Leucine dehydrogenase Bacillus sphaericus 125

• Nicotinic acid hydroxylase Achromobacter xylosoxidans 131

• Lipase Burkholderia plantarii 181

• Lactonase Fusarium oxysporum 220

• Penicillin amidase Escherichia coli 283

• Penicillin acylase Escherichia coli 290

• Aminoacylase Aspergillus oryzae 300

• Asparte .beta.-decarboxylase Pseudomonas dacunhae 334

• Fumarase Brevibacterium flavum 347

• Nitrile hydratase Rhodococcus rhodochrous 362

• Xylose isomerase Bacilluscoagulans/Strptomyces rubiginosus/Streptomyces phaechromogenes 387

• Dear reader 393

• Index

• Index of enzyme name 397

• Index of strain 400

• Index of company 403

• Index of starting material 406

• Index of product

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