Objective
To determine the effectiveness and safety of oral ketamine as an analgesic in neonatal circumcision using Plastibell®
Methodology
One hundred and twenty-one (121) neonates were sequentially recruited, and randomized into two groups of 55 each, with those in group A receiving oral ketamine and while those in group B received placebo (plain sucrose syrup). Each neonate was placed on continuous pulse oximeter monitoring before, during and immediately after the procedure. The procedure was carried out 30minutes after administration of the oral syrups. The pre-procedural percutaneous oxygen saturation (SpO2) and pulse rate (PR); the SpO2, PR, and neonatal infant pain scale (NIPS) score at the stages of adhesiolysis, dorsal-slit, tying and excision were recorded and analyzed for significant difference in the mean values between the two groups.
Results
Sixty-one (61) neonates in group A received oral ketamine, while sixty (60) neonates in group B received placebo. The mean ages and weight of the two groups were 15.2 days and 15.0 days, 3.67Kg and 3.63Kg, respectively. There was no statistical differences between these two groups in their age and weight (P= .509 and .692). The mean SpO2 (95.5 vs 95.6, 95.3 vs 94.4, 94.6 vs 93.5, 95.9 vs 94.8) was lower in the placebo group and was statistically significant at the tying stage with P= .022. The mean PR (158.1 vs 162.8, 165.5 vs 175.0, 179.6 vs 192.6, 161.5 vs 178.2) was higher in the placebo group and was statistically significant in a Mann-Whitney U test at dorsal-slit, tying and excision stages (P < .05). The mean NIPS scores (3.8 vs 4.9, 3.8 vs 4.9, 4.4 vs 4.9, 3.7 vs 4.8) were higher in the placebo group and significant in all the stages. These imply that oral ketamine produced significant analgesic effect during Plastibell® circumcision in the neonates in comparison to placebo. However a paired t-test of the mean pre-procedural and intra-procedural SpO2 and PR within the oral ketamine group shows significant difference. This points out that the analgesic effect produced by oral ketamine for this procedure is not yet ideal.
There were no statistically significant side effects noticed in the neonates who received oral ketamine. The noticed side effects required no intervention and were not life threatening.
Conclusion
Oral ketamine has significant analgesic effect during neonatal circumcision. Oral ketamine produced significant analgesic effect during Plastibell® circumcision in the neonates in comparison to sucrose and it is safe for use in neonates for procedures. Further research is necessary in order to explore the full benefits of orally administered ketamine in paediatric surgical practice.
Keywords
Oral ketamine, neonatal circumcision, Efficacy, Safety.