Abstract
The Longevity Genomics Research Project is designed to create a publicly-available research resource available through its website (www.longevitygenomics.org) to enable scientists to develop translational strategies to promote human longevity and healthy aging. Our resource will consist of software tools as R packages, curated datasets, and project results. We will identify Longevity-Associated Genes (LAGs) from Longevity-Associated Variants (LAVs), gene expression studies of aging, and evidence from model organisms. Mendelian Randomization using cohort studies with genetic data and longitudinal measures of aging-related traits will be used to evaluate the potential impact of modulating LAG’s on longevity. Candidate Longevity-Associated Drugs (LADs) that target LAG activity are then identified. Using sets of genes whose expression changes with age, we will report associations between genetically predicted expression of these genes and human survival, followed by connectivity map analysis to identify compounds that could target the expression of these genes.